I'm with Larry.

Humidity is taxing on the body but you can work through it, depending on health.
Besides west where water is disappearing, and cost of living is high, South East can be nice. South of the mason-dixion line and winter is typically no snow but can be in the 30's overnight. The lakes are clean and fresh you get hiking trails and plenty of outdoor activity.

However, unless you move to Nasville, Charlotte, etc. and commute to the lake, the lakes are not close to any city life.